About the role#
This co-op position is based in the Data and Computational Science department within the mRNA Center of Excellence. You will work on developing first-principle, machine-learning, and hybrid models to support mRNA-based process development. This role focuses on drug-product unit operations, including T-mixing and Tangential Flow Filtration (TFF).
What you'll do#
- Develop and validate first-principle, ML, and hybrid models for unit operations like T-mixing and TFF.
- Apply CFD, Molecular Dynamics, or Quantum Chemistry simulations to characterize mixing behavior, nanoparticle formation, and molecular-level interactions.
- Investigate how process parameters impact critical quality attributes.
- Quantify uncertainties using statistical and computational methods.
- Design and execute Design of Experiments (DoE) for model structure selection, parameter estimation, and process optimization.
- Analyze data from experiments and simulations to generate insights.
- Document modeling workflows, results, and recommendations in technical reports and presentations.
What you'll need#
- Pursuing a Master's or PhD in Chemical Engineering, Biochemical Engineering, Mechanical Engineering, Computational Science, Biomedical Engineering, Applied Mathematics, or a related quantitative field.
- Minimum cumulative GPA of 3.0 on a 4.0 scale.
- Foundational knowledge of mRNA technology, lipid nanoparticle formulation, or biopharmaceutical manufacturing processes.
- Experience developing physics-informed or physics-constrained ML, first-principle models, CFD, Molecular Dynamics, or Quantum Chemistry simulations.
- Proficiency in at least one modeling or programming tool, such as Ansys Fluent, Python, Julia, MATLAB, or gPROMS.
- Familiarity with Design of Experiments (DoE), uncertainty quantification, or Bayesian optimization.
- Strong written and verbal communication skills.
- Permanent authorization to work in the U.S. without sponsorship.
Location & details#
- Location: Waltham, Massachusetts.
- Term: Winter 2027.
- Schedule: Full-time, 40 hours per week, Monday to Friday.
- Work Modality: On-site.
- Enrollment: Must be enrolled in an accredited college or university throughout the duration of the co-op.
About Sanofi
Sanofi is a pharmaceutical manufacturing company based in Paris, France. It employs over 93,000 people across global offices. The company focuses on vaccines, rare diseases, neurology, immunology, and oncology. It also operates in the fields of diabetes, cardiovascular diseases, and consumer healthcare.
How to get in at Sanofi
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