About the role#
We are looking for a Master's-level Co-Op to join our Bioconjugation Chemistry team. You will focus on developing novel bioconjugation chemistries for site-selective protein modification. This is a hands-on laboratory role where you will design, synthesize, and evaluate reactive handles and conjugation strategies. You will work directly with chemists, protein engineers, and nanopore scientists to expand our toolkit for building next-generation protein conjugates.
What you'll do#
- Design and execute experiments to discover and optimize bioconjugation reactions on proteins and peptides.
- Synthesize small-molecule reagents, linkers, and probes, including purification and structural characterization.
- Screen reaction conditions under biocompatible conditions while assessing kinetics, selectivity, and yield.
- Characterize protein conjugates using intact-protein LC-MS to determine purity, conjugation efficiency, and site selectivity.
- Evaluate conjugate stability and the impact of modifications on protein structure and function.
- Maintain accurate records in an electronic lab notebook.
- Analyze data, summarize findings, and present results at team meetings.
- Contribute to a culture of safe laboratory practice and scientific rigor.
What you'll need#
- Current enrollment in an M.S. program for Chemistry, Chemical Biology, Biochemistry, or a related field.
- Exclusive eligibility for current Northeastern University Co-Op students.
- A strong foundation in organic synthesis, including multistep synthesis, purification, and characterization.
- Hands-on experience with NMR and LC-MS, with the ability to extract structural information from spectra.
- Working knowledge of protein chemistry, including handling, purification, and buffer considerations.
- Previous research or industry experience in bioconjugation, chemical biology, or protein modification.
- Familiarity with antibody or protein conjugate modalities.
- Ability to work independently, troubleshoot experiments, and think critically about results.
- Strong written and verbal communication skills and a collaborative mindset.
Location & details#
- Location: Cambridge, Massachusetts, USA.
- Work Modality: On-site, 5 days per week.
- Term: Winter 2027 to Summer 2027.
- Status: Full-time, 40 hours per week.
- Compensation: Paid position.
About Flagship Pioneering
Flagship Pioneering is a biotechnology firm based in Cambridge, Massachusetts. Founded in 2000, the company focuses on inventing and building platform companies that develop products for human health and sustainability. It has originated more than 100 scientific ventures since its inception. The current ecosystem includes over 40 companies, such as Indigo Agriculture and Generate:Biomedicines.
How to get in at Flagship Pioneering
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