About the role#
This co-op position focuses on testing whether the dual loss of RALA and RALB sensitizes pancreatic cancer cells to pan-KRAS inhibitors. You will gain hands-on wet-lab experience in target validation and mechanism of action studies. Your work will involve CRISPR and shRNA knockout and knockdown, dose-response combination assays, and PDAC organoid studies. The findings from this research will help determine if co-targeting RALA and RALB can improve responses to KRAS inhibitors.
What you'll do#
- Conduct full-time laboratory-based research to support oncology drug discovery.
- Maintain and manipulate 2D and 3D cell cultures, including organoids.
- Execute molecular biology, cellular biology, and biochemical assays.
- Perform gene transfer and genome editing using lentiviral and nucleofection methods.
- Use CRISPR/Cas, shRNA, and siRNA for target gene perturbation.
- Run cell viability and cytotoxicity assays.
- Perform RT-QPCR, western blot, RNA-seq, and co-immunoprecipitation.
- Mine published research to support experimental efforts.
- Analyze data, maintain detailed lab records, and present findings in team meetings.
What you'll need#
- Currently pursuing a BS, MS, or PhD in Molecular/Cell Biology, Cancer Biology, Genetics, Bioengineering, or a related field.
- Minimum 1-2 years of wet-lab experience.
- Technical proficiency in molecular and cell biology, genetics, or biochemistry.
- Relevant research experience in an industry or academic setting.
- Broad hands-on experience with cell and molecular biology methods.
- Ability to work independently and as part of a collaborative team.
- Clear written and verbal communication skills.
- Legal authorization to work in the United States without sponsorship.
Location & details#
- Location: Cambridge, Massachusetts.
- Work Modality: On-site.
- Employment: Full-time.
- Compensation: $24.00 - $45.00 per hour.
About Bristol Myers Squibb
Bristol Myers Squibb is a public pharmaceutical company founded in 1887. It focuses on research and development in areas such as oncology, hematology, immunology, and cardiovascular disease. The company maintains its headquarters in Lawrence Township, New Jersey. It employs over 38,000 people across various global locations.
How to get in at Bristol Myers Squibb
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