About the role#
The Long Read Sequencing Co-Op is a 6-month experiential program for students pursuing an advanced degree in Biological Sciences or related fields. You will join the BSMO CGT AD functional areas to gain hands-on experience in long read sequencing applications. This role requires full-time commitment from January through July 2027.
What you'll do#
- Characterize stem cells and stem cell derived pancreatic islets using RNA sequencing for modification and isoform analysis.
- Conduct plasmid integration analysis to assess monoclonal antibody-producing cell lines.
- Verify monoclonal antibody heavy- and light-chain sequences and support variant calling using direct RNA or cDNA sequencing.
- Evaluate mRNA integrity and polyA tail characterization.
- Establish new workflows and assays to support long read sequencing applications.
- Execute experiments and analyze datasets using statistical methods.
What you'll need#
- Currently enrolled in a Master's or PhD program in Biological Sciences or a related field (must be enrolled if graduating before June 2027).
- Experience with Oxford Nanopore systems.
- Proficiency with R or Python, Linux, and high process computing systems.
- Knowledge of nucleic acid extraction, cDNA preparation, and sequencing library preparation.
- Familiarity with bioinformatics tools including minimap2 and samtools.
- Knowledge of data analysis tools such as DESEQ2 and Gene Set Enrichment Analysis.
- Ability to design and analyze experiments for analytical assay development.
Location & details#
- Location: Boston, Massachusetts.
- Work Modality: On-site (5 days per week).
- Term: Winter 2027 (January - July).
- Employment: Full-time, paid.
- Note: This role does not provide visa sponsorship.
About Vertex Pharmaceuticals
Vertex Pharmaceuticals is a biotechnology company founded in 1989. It focuses on scientific research to develop medicines for serious diseases such as cystic fibrosis, sickle cell disease, and various forms of pain. The company maintains its global headquarters in Boston and operates research and commercial sites across the globe. It employs between 5,001 and 10,000 people.
How to get in at Vertex Pharmaceuticals
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